Keratin 15

KRT15
Identifiers
Aliases	KRT15, CK15, K15, K1CO, keratin 15
External IDs	OMIM: 148030; MGI: 96689; HomoloGene: 1712; GeneCards: KRT15; OMA:KRT15 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,522,529 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,026,754 bp
RNA expression pattern
	Top expressed in
	mucosa of pharynx; ; skin of thigh; ; skin of arm; ; skin of abdomen; ; epithelium of nasopharynx; ; gums; ; gingival epithelium; ; cervix epithelium; ; vulva; ; skin of hip;
	Top expressed in
	conjunctival fornix; ; skin of abdomen; ; lip; ; esophagus; ; transitional epithelium of urinary bladder; ; skin of external ear; ; cornea; ; skin of back; ; umbilical cord; ; trachea;
	More reference expression data
	n/a
Gene ontology
Molecular function	scaffold protein binding; structural constituent of cytoskeleton; protein binding; structural molecule activity;
Cellular component	extracellular exosome; intermediate filament; nucleus; cytosol;
Biological process	epidermis development; cytoskeleton organization; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3866
	16665
	ENSG00000171346
	ENSMUSG00000054146
	P19012
	Q61414
	NM_002275
	NM_008469
	NP_002266
	NP_032495
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated: 2025-08-06 14:26:34

Keratin 15

Keratin 15 is a protein that in humans is encoded by the KRT15 gene.^[5]^[6] It has also been referred to as cytokeratin 15, K1CO and KRTB.

Keratin 15 is a type I cytokeratin. It is well-expressed in the basal layer of complex epithelia. However, acral keratinocytes express little to no keratin 15.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171346 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054146 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Barletta C, Batticane N, Ragusa RM, Leube R, Peschle C, Romano V (1990). "Subchromosomal localization of two human cytokeratin genes (KRT4 and KRT15) by in situ hybridization". Cytogenetics and Cell Genetics. 54 (3–4): 148–150. doi:10.1159/000132979. PMID 1702379.
↑ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, et al. (July 2006). "New consensus nomenclature for mammalian keratins". The Journal of Cell Biology. 174 (2): 169–174. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
↑ Merleev AA, Le ST, Alexanian C, Toussi A, Xie Y, Marusina AI, et al. (August 2022). "Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes". JCI Insight. 7 (16): e159762. doi:10.1172/jci.insight.159762. PMC 9462509. PMID 35900871.

Radoja N, Stojadinovic O, Waseem A, Tomic-Canic M, Milisavljevic V, Teebor S, Blumenberg M (April 2004). "Thyroid hormones and gamma interferon specifically increase K15 keratin gene transcription". Molecular and Cellular Biology. 24 (8): 3168–3179. doi:10.1128/MCB.24.8.3168-3179.2004. PMC 381600. PMID 15060141.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Rittié L, Stoll SW, Kang S, Voorhees JJ, Fisher GJ (December 2009). "Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin". Aging Cell. 8 (6): 738–751. doi:10.1111/j.1474-9726.2009.00526.x. hdl:2027.42/78718. PMID 20050020. S2CID 8832389.
Waseem A, Dogan B, Tidman N, Alam Y, Purkis P, Jackson S, et al. (March 1999). "Keratin 15 expression in stratified epithelia: downregulation in activated keratinocytes". The Journal of Investigative Dermatology. 112 (3): 362–369. doi:10.1046/j.1523-1747.1999.00535.x. PMID 10084315.
Blumenberg M, Savtchenko ES (1986). "Linkage of human keratin genes". Cytogenetics and Cell Genetics. 42 (1–2): 65–71. doi:10.1159/000132253. PMID 2424675.
Marchuk D, McCrohon S, Fuchs E (March 1985). "Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene". Proceedings of the National Academy of Sciences of the United States of America. 82 (6): 1609–1613. Bibcode:1985PNAS...82.1609M. doi:10.1073/pnas.82.6.1609. PMC 397321. PMID 2580298.
Bader BL, Jahn L, Franke WW (December 1988). "Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene". European Journal of Cell Biology. 47 (2): 300–319. PMID 2468493.
Choi CW, Park HS, Kim YK, Lee SH, Cho KH (August 2008). "Elastic fiber staining and cytokeratin 15 expression pattern in trichoepithelioma and basal cell carcinoma". The Journal of Dermatology. 35 (8): 499–502. doi:10.1111/j.1346-8138.2008.00510.x. PMID 18789069. S2CID 36019385.
Romano V, Bosco P, Rocchi M, Costa G, Leube RE, Franke WW, Romeo G (1988). "Chromosomal assignments of human type I and type II cytokeratin genes to different chromosomes". Cytogenetics and Cell Genetics. 48 (3): 148–151. doi:10.1159/000132612. PMID 2466616.
Leube RE, Bader BL, Bosch FX, Zimbelmann R, Achtstaetter T, Franke WW (April 1988). "Molecular characterization and expression of the stratification-related cytokeratins 4 and 15". The Journal of Cell Biology. 106 (4): 1249–1261. doi:10.1083/jcb.106.4.1249. PMC 2114990. PMID 2452170.
Hanukoglu I, Fuchs E (November 1982). "The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins". Cell. 31 (1): 243–252. doi:10.1016/0092-8674(82)90424-X. PMID 6186381. S2CID 35796315.
Celis JE, Gromova I, Cabezón T, Gromov P, Shen T, Timmermans-Wielenga V, et al. (December 2007). "Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15: relationship between CK15+ progenitor/amplified cells and pre-malignant lesions and invasive disease". Molecular Oncology. 1 (3): 321–349. doi:10.1016/j.molonc.2007.09.004. PMC 5543867. PMID 19383306.
Werner S, Munz B (January 2000). "Suppression of keratin 15 expression by transforming growth factor beta in vitro and by cutaneous injury in vivo". Experimental Cell Research. 254 (1): 80–90. doi:10.1006/excr.1999.4726. PMID 10623468.
Whittock NV, Eady RA, McGrath JA (January 2000). "Genomic organization and amplification of the human keratin 15 and keratin 19 genes". Biochemical and Biophysical Research Communications. 267 (1): 462–465. doi:10.1006/bbrc.1999.1966. PMID 10623642.
Al-Refu K, Goodfield M (May 2009). "Hair follicle stem cells in the pathogenesis of the scarring process in cutaneous lupus erythematosus". Autoimmunity Reviews. 8 (6): 474–477. doi:10.1016/j.autrev.2008.12.015. PMID 19162247.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171346 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054146 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1702379-5] Barletta C, Batticane N, Ragusa RM, Leube R, Peschle C, Romano V (1990). "Subchromosomal localization of two human cytokeratin genes (KRT4 and KRT15) by in situ hybridization". Cytogenetics and Cell Genetics. 54 (3–4): 148–150. doi:10.1159/000132979. PMID 1702379.

[pmid16831889-6] Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, et al. (July 2006). "New consensus nomenclature for mammalian keratins". The Journal of Cell Biology. 174 (2): 169–174. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.

[7] Merleev AA, Le ST, Alexanian C, Toussi A, Xie Y, Marusina AI, et al. (August 2022). "Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes". JCI Insight. 7 (16): e159762. doi:10.1172/jci.insight.159762. PMC 9462509. PMID 35900871.

[1]

Keratin 15

References

Further reading